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More importantly, chronic exposure to HMs disrupts both innate and adaptive immune systems, typically inducing inflammatory reactions

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In addition, alkylation, acylation, or guanidinylation of the -amino group can finely tune basicity, hydrogen-bond donor/acceptor properties, and lipophilicity, thereby optimizing the efficacy and toxicological profiles of lead compounds

Receiver operating characteristic curve Using the Receiver Operating Characteristic (ROC) curve, the predictive value of Vitamin D for Neuropathic Pain (NP) was explored