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438 Theophylline, a Phosphodiesterase 4 (PDE4) inhibitor, is another drug that promotes apoptosis by reducing the anti-apoptotic protein Bcl-2, which inhibits neutrophils and eosinophils in vitro

Llibre Rodrguez JJ, Valhuerdi Cepero A, Calvo M, Garca RM, Guerra M, Laucerique T, et al

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Granulomatous inflammation is a defining feature of sarcoidosis and hypersensitivity pneumonitis, where antigen-driven immune responses lead to non-caseating granuloma formation and immune complex-mediated lung damage [7]