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While hyperpigmentation can be caused by too much sun exposure, it may be the result of other factors, such as hormonal changes, skin injuries, inflammation, or age

A key structural feature is a cyclopentanone ring resembling that in mammalian prostaglandins (surely no coincidence although the biosynthetic mechanisms are very different), but the stereochemistry of the active species has until recently been a cause of confusion

Abstract Albumin has a long plasma half-life due to engagement of the neonatal Fc receptor (FcRn), which prevents intracellular degradation

For analysis, rBFI response to VM was divided into 4 phases shown in Fig

Compounds such as RSL3 irreversibly inhibit GPX4 by binding to its active site, resulting in LPO accumulation and ferroptotic cell death (Fang et al., 2019)