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suppresses TGF--driven fibrosis and cardiac/renal remodeling: PMC4889319

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These were all 5-HT1b agonists characterized for their ability to inhibit food consumption, but also had effects on other serotonin receptors that lead to unacceptable side effects (cardiac valvular thickening) and were voluntarily withdrawn from the market

Neelakantan H, Vance V, Wetzel MD, Wang H-YL, Mchardy SF, Finnerty CC, Hommel JD, Watowich SJ (2018) Selective and membrane-permeable small molecule inhibitors of nicotinamide N -methyltransferase reverse high fat diet-induced obesity in mice