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Early jowling, for example, is often a problem of ligament relaxation and dermal thinning rather than volume loss alone

The most frequent symptoms are: Developmental delays Anaemia Loss of appetite Chronic vomiting Weight loss Low brain volume Spasms/cramps Apathy Irritability In the most severe instance, vitamin B12 deficiency can lead to respiratory failures and coma (51)

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Dysregulation of thiol metabolism leads to oxidative stress and other metabolic dysfunctions, which are directly implicated in neurodegeneration 1 , cardiovascular diseases 2 , and cancer 3

Analysis scripts and notebooks used for this study are open-source and available from GitHub ( Any additional information required to reanalyze the data reported in this work paper is described in the Methods and available upon request from the corresponding authors