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More importantly, treatment with APG-157 led to a reduction in pro-inflammatory cytokines IL-1, IL-6, and IL-8 in the saliva of these cancer patients ( A Phase II trial (ongoing or recently completed) is testing APG-157 in combination with a checkpoint inhibitor (immunotherapy) in oral cancer, based on preclinical suggestions that curcumin may improve anti-tumor immunity (Xiang et al., 2019)

Molecules 28 , 2413

INGREDIENTS : Sodium ascorbate, L-Glutathione, Phosphatidylcholine, Vegetable capsule (Hydroxypropyl methylcellulose)

88 In knockout mouse melanoma cells, nilotinib was found to upregulate MITF (melanocyteinducing transcription factor) and its downstream genes via activation of the cAMP/PKA/CREB pathway and decreased phosphorylation of AKT

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