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Lipidomic analyses indicate that phosphatidylethanolamines (PEs) containing arachidonic acid (AA) or adrenic acid (AdA) are key membrane phospholipids and are further oxidized to phospholipid hydroperoxides (PE-AA/AdA-OOH) by non-enzymatic processes, such as the above mentioned free radical lipid peroxidation or Fenton chemistry drives ferroptosis (Doll et al., 2017

doi: 10.1111/bdi.12980 114 DimopoulosNPiperiCPsarraVLeaRWKalofoutisA

J Neurochem 2000

Mo et al., 2016), which decreased as RPCs differentiated into photoreceptors, and are accompanied by increased expression (Solovei et al., 2009)

1996;104 Suppl 5:9016