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Oral doses tend to be higher - 500 mcg to 1000 mcg twice daily - because oral bioavailability is presumably lower than injectable, though we don't have good human pharmacokinetic data

Treatment with modified SP-B mRNA, administered twice weekly for four weeks, relieved respiratory distress and increased the mean lifespan to 26.2 2.7 days, compared to only 3.7 0.3 days in the control group receiving eGFP-Luc mRNA

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