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47 In addition, rodent GH does not activate the human or primate GHR, so the use of pegvisomant in animal models of disease does not address the effect of the blockade of systemic GH

32 ZhangC.XieY.ChenH.LvL.YaoJ.ZhangM.et al (2020)

In addition, the expression of TNF-, FN and -SMA were reduced

Pubertal patients with advanced CKD have a reduced GH secretion rate, indicating altered sensitivity of somatotropic hormones to the stimulatory effects of sex steroids [10]