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This experimentation led to an upregulation of neurogenic differentiation markers, including Nestin, GAP43, Tubulin III, and Doublecortin, in hGMSCs

The strength of this axis varies with sex and age, exemplified by estrogenSIRT3 signaling and NRF2 capacity, and is reset by epigenetic control through DNA methylation and lncRNA or miRNA networks across ischemiareperfusion and sepsis