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This can happen anywhere along its path, but most often originates in the lower back (lumbar spine)

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Pronounced analgesic and neuro-regenerative effects are produced by this high dosage combination and is therefore particularly valuable in the treatment of disorders of peripheral nervous system: polyneuritis, neuralgia, sciatica and shoulder-arm syndrome, lumbago-lumbalgia, intercostal neuralgia, trigeminal neuralgia, facial palsy due to herpes zoster, diabetic neuropathy, optic neuritis, numbness of the extremities, as a supplement to therapy with INH, reserpine and phenothiazines, nausea and vomiting of pregnancy, vitamin B deficiency, cerebrovascular accidents

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