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BBB structure and physiology Anatomical structure of the BBB The existence of the BBB was first found by Paul Ehrlich and proved by Edwin Goldmann

[DOI] [PMC free article] [PubMed] [Google Scholar] [346].Zheng X, Yoo MJ, Hage DS, Analysis of free fractions for chiral drugs using ultrafast extraction and multi-dimensional high-performance affinity chromatography, Analyst 138 (2013) 62626265

In recent work, Lopes and colleagues demonstrated that caffeine increased the energy charge and redox state of cortical synaptosomes, suggesting that this effect led to an increase in the glycolytic rate, thereby enhancing astrocyte-synapse lactate transport

In a clinical trial conducted by Rhodes [77] on 16 healthy white volunteers exposed to a UV simulator composed of UVA and UVB radiation sources to induce skin photoaging damage, it was found that oral administration of GTE containing 40.3% EGCG and vitamin C for 12 weeks effectively inhibited UV irradiation-induced skin inflammation and that the level of inflammatory mediator 12-hydroxyeicosatetraenoic acid was reduced while PGE2 did not change