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Reference: Hsieh et al., 2017 (VEGFR2AkteNOS signalling involvement) VEGFR2 activation triggers: VEGF binding VEGFR2 autophosphorylation (turns on VEGFR2) which leads to PI3K activation which leads to Akt phosphorylation Akt (Protein Kinase B) is critical because it phosphorylates (turns on) eNOS which leads to Nitric oxide synthesis more nitric oxide

Depending on your health goals, weekly or bi-weekly injections are common

Nevertheless, the IM route of either OH-Cbl or CN-Cbl remains more established and widely recommended for treatment of B12 deficiency

The practical implication is straightforward