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Each enzyme molecule showed two polar interactions with amlodipine, and they linked through the following residues: for A through arginine (Arg)residues: Arg-252 and Arg-398, for G through Arg-608 and methionine (Met)363, and for SI Arg-58 and Gln-57

G., Chigurupati, S., Hanig, J., Ferguson, S

Li, W., Wang, T., & Xiao, S

3 Sources and mechanism of ROS generation ROS, sometimes called biradical or paramagnetic species, are very reactive molecules that emerge when oxygen molecules receive an electron due to their radical nature [22]

however, it encounters significant bioavailability challenges that may limit therapeutic effectiveness [74, 76]