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Deficits in hippocampal neurogenesis in obesity-dependent and -independent type-2 diabetes mellitus mouse models

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Also, decreased glutathione levels caused motor neuron degeneration in the hSOD1 wt over-expressing mice model (hemizygous mice over-expressing wild-type hSOD1 at moderate levels) (Killoy et al., 2018) and accelerated motor neuron death in SOD1 G93A mice (Pehar et al., 2014)

MDA, a reactive aldehyde, belongs to a class of reactive electrophile species that induce toxic stress in cells and form covalent protein adducts known as advanced lipoxidation end products, similar to advanced glycation end products