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The European Respiratory Journal Geiler J at al., (2010), N-acetyl-L-cysteine (NAC) inhibits virus replication and expression of pro-inflammatory molecules in A549 cells infected with highly pathogenic H5N1 influenza A virus, Biochemical Pharmacology McCarty at al.(2020), Nutraceuticals have potential for boosting the type 1 interferon response to RNA viruses including influenza and coronavirus, Progress in Cardiovascular Diseases Palacio at al., (2011) Anti-inflammatory properties of N-acetylcysteine on lipopolysaccharide-activated macrophages, Inflammation Research Sadowska et al.,(2006), Role of N-acetylcysteine in the management of COPD, International Journal of Chronic Obstructive Pulmonary Disease Schmitt et al.,(2015), Effects of N-acetylcysteine, oral glutathione (GSH) and a novel sublingual form of GSH on oxidative stress markers: A comparative crossover study, Redox Biology Zhang et al.,(2018), N-acetylcysteine improves oxidative stress and inflammatory response in patients with community acquired pneumonia, Medicine

The rate-limiting step in extracellular GSH catabolism is controlled by -glutamyltransferases (GGTs), which cleave the -glutamyl bond in GSH to release glutamate and dipeptide cysteinylglycine

VEGF-A, Vascular Endothelial Growth Factor A

Upon entering the cell, ALA facilitates the release of Nrf2 from its inhibitory complex, allowing it to travel to the nucleus and bind to the Antioxidant Response Element (ARE) on the DNA

That is, a compound of Formula (I) and any of the agents described above can be formulated together in the same dosage form and administered simultaneously