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In animals, VC can be synthesized by the organism, acquired through the diet, or both

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TCA cycle intermediates were undetectable when [ 15 N, 13 C 5 ]valine was used as substrate, likely reflecting the low intrinsic levels of BCAT in the human liver and the further decrease in expression of metabolic genes (including BCAT) known to occur upon plating of hepatocytes

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These SCFAs supply key metabolic signaling that underlies homeostasis and the function of colonic Tregs by different molecular mechanisms (Mu et al., 2017