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[1] The formulation delivers 17-estradiol in a depot that slowly releases hormone over several weeks, thereby potentially supporting more stable serum estrogen concentrations than daily oral or transdermal preparations and potentially improving symptom control for individuals with hypoestrogenism or menopausal vasomotor instability

This can be due to weakening of the stomach lining (also known as atrophic gastritis), or to medications that reduce stomach acid

Side effects are uncommon and typically limited to mild injection site reactions

DSIP has been linked to increased levels of serotonin, a neurotransmitter that contributes to feelings of well-being and happiness

On regression analysis, hypoperfused volumes on CTP were associated with excellent outcomes (odds ratio [OR] 1.02, 95% confidence intervals [CI] 1.001-1.037) whereas core volume was not