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2016;11:e0166388

The production of ROS is mainly secondary to enzymatic reactions involved in the respiratory chain, activity of cytochrome p-450, synthesis of prostaglandins and phagocytosis (Pizzino et al., 2017)

These opposing roles of distinct PRDX isoforms suggest that PRDXs function not simply as antioxidant enzymes but as context-dependent determinants of ferroptosis sensitivity