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(Weinh) 10 (15), e2207366

Similarly, in male mice, a biogenic immune stressor producing sustained IFN- elevations induced chronic increases in both peripheral and brain IDO activity, accompanied by widespread TRP depletion, indicating that prolonged cytokine signalling drives central and peripheral TRP loss [68]

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AOD9604 was originally developed after research on mice, but subsequent studies in human have shown no efficacy for the potential treatment of obesity