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231 found that riluzole (Fig

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Mechanistically, HGF inhibits inflammatory M1-like macrophage production of pro-inflammatory cytokines and chemokines (such as IL-1, IL-6, TNF, CXCL1, CXCL10, and CCL2) by disrupting nuclear factor NF-B signaling (Giannopoulou et al., 2008) through the enhancement of the heme oxygenase-1 (HO-1) transcriptional pathway and the inactivation of the GSK-3 pathway (Kamimoto et al., 2009a,b

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A total of 8 segmental duplication events- SlGSTU 16/ SlGSTU 55, SlGSTU 18/ SlGSTU 52, SlGSTU 19/ SlGSTU 53, SlGSTU 19/ SlGSTU 50, SlGSTU 29/ SlGSTU 51, SlGSTU 46/ SlGSTU 47, SlGSTU 49/ SlGSTU 52 and SlGSTU 56/ SlGSTU 47 are detected in SlGST family but lack of tandem duplication (Table 2)