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acidophilus ) with a diagnosis of bipolar I disorder and no significant differences on mania or depression rating scales were found, emphasizing that pinpointing strains and duration for treatments needs refinement

However, some natural compounds, such as 8 alkaloids [berberine hydrochloride (Zhu et al., 2019a), berberrubine (Yu et al., 2018), coptisine (Wang et al., 2021a), dihydroberberine (Li et al., 2021), evodiamine (Shen et al., 2019), matrine (Yan et al., 2020), nigakinone (Liu et al., 2023), and piperine (Guo et al., 2020)], 8 flavonoids [apigenin (Qu et al., 2021), licochalcone A (Zhang et al., 2021), licoflavone B (Zhang et al., 2022b), phloretin (Zhang Z

(2016) 137:18091821.e1812

PMCID: PMC2129149