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But for some, recovery isnt so straightforward, and some children can continue to experience long term effects of concussion weeks, or even months, after the initial injury in areas like emotional regulation and gut-brain dysfunction

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A CRISPR/Cas9-mediated knockout of the GLA gene together with the overexpression of a number of different mutant variants allowed establishing a correlation between enzyme activity levels and ER retention [54] and, thereby, furthered the understanding of the full clinical presentation of Fabry disease

264 The inhibition of mTOR with rapamycin has demonstrated promising effects in vitro, but clinical trials have shown limited efficacy, 265 suggesting the need for combination therapies

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