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Certain medications may make RLS symptoms worse, for example, medicines that address mental health (antidepressants, antipsychotics) and even over-the-counter medications for allergies and cold symptoms (4)

Skin elasticity presents another concern

Patients whose labs improved but fatigue, sleep disruption, or focus issues did not meaningfully change

One is by helping you use your food more efficiently so you get more energy from it

And that is not observed: Children with IGF1 defects suffer from far more severe fetal growth retardation with birth weight SDS around -4 and birth length SDS of -5 to -6 (reviewed in (58)