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In vivo demonstration Conceptual extension of emerging in vitro findings was performed by testing the potential effect of oral LASSS administration on prevention of muscle disuse-induced nitration-dysfunction of ECM-bound HGF (at Y198 and Y250 in K1 and K2 domains, respectively) 64

Sample collection After the last weighing, these experimental animals were fasted for 24 hrs with free drinking water

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10.1038/s41586-019-1705-2 6 BerthelootD.LatzE.FranklinB

Third, regulatory decisions should be grounded in robust clinical evidence rather than extrapolation from incomplete preclinical data