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A properly installed and maintained backwater valve allows sewage to go out, but not to come back in

The surgical approach is tailored to the individual patient

doi: 10.3389/fphar.2025.1602976 Received 30 March 2025 Revised 13 November 2025 Accepted 14 November 2025 Published 19 December 2025 Volume 16 - 2025 Edited by Bernd Rosenkranz, Fundisa African Academy of Medicines Development, South Africa Reviewed by Kacper Nijakowski, Poznan University of Medical Sciences, Poland Miriam Njoki Karinja, Science for Africa Foundation, Kenya Updates Copyright 2025 Mazur, Ndokaj, Salerno, Vallone, Ardan, Bietolini, Carrouel, Wilk, Sarig, Ottolenghi and Bourgeois

Newly discovered type of programmed cell death, ferroptosis, has been demonstrated to play a crucial role in many cancers

While cellular consumption is partially responsible for the concentration and in turn metabolic gradients observed in vivo , relying on them in in vitro poses an important risk due to the high variability of cellular metabolism in different donors especially for human subjects