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SPIRITT: a randomized, multicenter, phase II study of panitumumab with FOLFIRI and bevacizumab with FOLFIRI as second-line treatment in patients with unresectable wild type KRAS metastatic colorectal cancer

The junctional adhesion proteins (JAMs) are involved in the formation of the tight junction, and lower expression of JAM2 has been associated with CRC disease progression, metastasis and poor prognosis, indicating JAM2 as a tumour suppressor (97)

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With immunothrombosis being one of the proposed mechanisms in COVID-19 infection, we wanted to investigate this process and hypothesized that L-GSH supplementation would reduce fibrin clot formation within the PBMC cultures by reducing ROS and assisting in fibrin clearance