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It has been shown that HDAC2 is excessively ubiquitinated and degraded in the proteasome, an action attributed to the low expression of USP17 in CS-exposed airway epithelial cells and macrophages, while overexpressed USP17 blocks the degradation of HDAC2 induced by CS [77]

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Our improved understanding of both the health effects and associated costs has helped us establish that these health and economic impacts are higher than previously reported

Iloreta, who's seen a range of patients with anosmia and parosmia, as well as taste conditions, said there's "a wide spectrum of presentations." Some patients notice decreases in their perception of flavors and odors, whereas others notices changes in these senses