l carnitine and liver disease Deficiency: What Is It, Causes, Symptoms, More Effect of L-Carnitine Supplementation on

Disclosures: Allison Carroll: Nothing to Disclose, Wolfram Goessling: Nothing to Disclose, Marc Sherman: Nothing to Disclose 2430 FXR AGONIST INT-787 INHIBITS INFLAMMATION, FIBROSIS, SENESCENCE, AND APOPTOSIS ARREST IN HUMAN CHOLANGIOCYTES MODELING PSC Francesca De Franco 1 Daniela Passeri 1 Sanjay Kansra 2 Luciano Adorini 2 Mary Erickson 2 Roberto Pellicciari 1 , 1 TES Pharma S.r.l., Perugia, Italy, 2 Intercept Pharmaceuticals, Inc., Morristown, New Jersey, USA Background: Cholangiocyte senescence is present in all stages of primary sclerosing cholangitis (PSC) and is associated with disease severity

This inhibitory effect on monocytes TNF and IL-1 production was confirmed in human whole blood and human monocyte/macrophages using a selective inhibitor of 7 nicotinic acetylcholine receptor (7nAChR) (86)

HPV infection is associated with reduced levels of key metabolites, including nicotinamide, succinate, and dipeptides (e.g., cysteinylglycine and cysteinyl) (McKenzie et al., 2021) as well as both oxidized and reduced glutathione (Lebeau et al., 2022)

This can bring about thicker, more durable skin, and also reverse defective pigmentation

The new peptide targets a protein called Mcl-1, which helps cancer cells avoid the cellular suicide that is usually induced by DNA damage