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Colorectal cancer frequently metastasizes to the liver, a major contributor to its high mortality

Future research will focus on decoding metabolic regulationsuch as CSF1R-mediated resting-state energy metabolism and AMPK/mTOR-controlled activated-state metabolic remodelingand targeting BDNF neurotrophic or TNF- pro-inflammatory signaling to develop precision therapies for neurodegenerative diseases, leveraging microglial metabolic-immunological crosstalk (Salter and Stevens, 2017)

In addition, the development of cell-penetrating peptides targeting the inhibition of specific modified proteins or small molecule compounds antagonizing related modifications may also emerge as effective tumor treatment strategies