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Tregs exert suppressive immune regulation through multiple mechanisms, including the secretion of IL-35, IL-10, and other soluble suppressive immune molecules, to suppress effector signals directly

Ferdinandi ES, Brazeau P, High K, Procter B, Fennell S, Dubreuil P

77 In addition to functioning as pathogenic triggers in different tumors, ncRNAs present in extracellular vesicles in the TME also hold promise for assessing therapeutic response