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The following symptoms may indicate a B12 deficiency: Signs of anaemia such as pallor, tiredness, palpitations Skin and mucous membrane changes such as glossitis (inflammation of the tongue), smooth red tongue, tongue burning [7] and hyperpigmentation of the skin Neurological symptoms: Tingling in arms and legs (paraesthesia) to numbness, dizziness, depression, forgetfulness, unsteadiness in gait, listlessness to psychosis and paralysis Why do you get nerve and leg pain with a vitamin B12 deficiency

tell the clinic if you take a high-strength biotin supplement

However, those with specific autoimmune conditions (particularly psoriasis or rosacea, where LL-37 is naturally overexpressed locally) should consult with their healthcare provider, as adding exogenous LL-37 could potentially exacerbate hyper-immune responses in those highly specific contexts