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BMJ 340:c2181 Rodrguez-Gutirrez R et al (2017) Metformin use and vitamin B12 deficiency: untangling the association

NAD+ has been shown to lower blood pressure which can help to reduce the risk of cardiovascular diseases

At least not yet

Similarly, clinicians, policy-makers, and people with obesity may find the mean weight loss of a treatment of little practical or planning value, while the proportions of people achieving categorical weight loss of 5, 10, and 15% might be more relevant to inform real-world clinical practice