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This dual-compound approach facilitates examination of synergistic pathway interactions while maintaining precise experimental control over individual molecular mechanisms through separate component analysis

*Correspondence: Qian Lin, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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In brief, for total RNA-seq data, we tested the fold-change and significance between each pair of conditions using a negative binomial Wald test, and genes with a Benjamini and Hochberg-corrected p value lower than 0.05 were considered statistically significant, unless stated otherwise

C.JerominA.VanmechelenE.BlennowK.et al