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No Rebound Hunger or Metabolic Adaptation Appetite suppressants that work through central mechanisms (GLP-1 agonists, sympathomimetics, serotonergic agents) typically create tolerance over time, requiring dose escalation, and often produce rebound hunger when discontinued

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These factors not only enhance the migration and proliferation of ECs but also further skew macrophage polarization away from M1 to the tumor-promoting M2 phenotype 44,47,48

J Pharmacol Exp Ther 272:417422, 1994 Veljaca M, Lesch CA, Sanchez B, Low J, Guglietta A: Protection of BPC-15 on TNBS-induced colitis in rats: Possible mechanisms of action

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