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Phentermine is typically prescribed for individuals with a Body Mass Index (BMI) of 30 or higher or for those with a BMI of 27+ who have weight-related health conditions like high blood pressure or diabetes and have not been able to lose weight effectively through diet and exercise alone

195,196,197 At the cellular level, this translates into a massive increase in cytoplasmic Na + concentration, membrane depolarisation and opening of voltage-gated Ca 2+ channels, which in turn promotes massive release of glutamate that results in even large depolarisation enlarging Na + and Ca 2+ influx thus completing the vicious circle of excitotoxic damage, as Ca 2+ overload triggers necrotic cell death

Bleeker JC, Houtkooper RH

Demeclocycline and minocycline cause a similar interaction

Overwhelming scientific evidence in its favor is why FDA has approved PT 141