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If such a vicious cycle of glutamate excitotoxicity, oxidative stress, and mitochondrial dysfunction does indeed underpin ME/CFS pathology, it may not be clear where exactly the root problem lies

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31,139 Chemotaxis encompasses three interrelated processes: the periodic extension of typical pseudopods, the establishment of cellular polarity that heightens anterior sensitivity relative to the posterior, and orientation sensing, which continuously aligns the chemotaxis with the external gradient

GCL is a heterodimeric enzyme composed of a glutamate-cysteine ligase catalytic subunit (GCLC), which confers enzymatic activity, and a glutamate-cysteine ligase modifier subunit (GCLM), which enhances GCLC efficiency and attenuates feedback inhibition by GSH