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While the implications for SARM1 in regulating axonal fate are well-established, the sensing mechanisms of this protein complex toward NAD + , NMN, or even possibly toward other NAD + metabolites are not fully understood, and may suggest that also the other NAD + metabolites could regulate more biological processes than initially thought 54

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iron must be in a divalent (Fe 2+ ) state or combine with a transporter protein to be absorbed by intestinal epithelial cells

Regulation of Ferroptosis through GPX4 GPX4 was first recognized in 2014 as a key regulator of ferroptotic cell death by Yang et al