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Of note, GFAP is produced by activated astroglia that release ROS and pro-inflammatory mediators, creating a vicious cycle between oxidative stress and inflammation and hence playing a vital role in neuroinflammation with its subsequent neuronal apoptosis and hence neuronal damage (Colombo and Farina 2016)

The ferroptosis inducers ART and erastin both caused a time-dependent increase in GRP78 expression and induced ERS

J Am Chem Soc 116:67396744 Yang YH, Jing LH, Yu XL, Yan DD, Gao MY (2007) Coating aqueous quantum dots with silica via reverse microemulsion method: toward size-controllable and robust fluorescent nanoparticles

Briefly, HK-2 cells were seeded in 96-well plates at a density of 5,000 cells per well and allowed to adhere overnight

Since storage additives are devoid of amino acids, elevation in intracellular amino acids is consistent with proteolysis (e.g., via proteasomal degradation), a phenomenon that is mechanistically linked to (extravascular) hemolysis 45