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R -lipoic acid occurs naturally in food (see Food sources)

Lyophilization, also known as freeze-drying, is a drying method that removes water from a material in the form of ice crystals through sublimation under low pressure [17,18,19]

PARP inhibitors Given that PARP inhibitors have mainly been used for the treatment of different types of cancer, rather than for their potential as NAD + enhancers, the majority of adverse effects are reported in relation to the treatment of cancer patients