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AFB 1 induced transcriptional regulation related to apoptosis and lipid metabolism in liver of chicken

(Ye et al., 2009

4 Relevant mechanisms affecting the occurrence of cuproptosis 4.1 Copper overload disrupts the synthesis of Fe-S cluster proteins Fe-S clusters are cofactors made up of iron and inorganic sulfur, which play a crucial role in a variety of biological processes, including mitochondrial energy production, amino acid synthesis, cofactor synthesis, and tRNA modification (Lill, 2009)

Taking into account the importance of MPTP, as a model for PD, it seems that further epidemiological research is needed to address more thoroughly the role of MPTP in astrocytic damage and PD development