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Together, this platform demonstrates that spatially controlled intracellular synthesis of PROTACs via tumor-targeted nano-assembly enhances degradation efficacy, overcomes the hook effect, and minimizes off-target toxicityproviding a robust and clinically promising strategy for precision protein degradation

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doi: 10.1016/j.neuroscience.2016.01.010 214

Enhanced acetylation of ATP-citrate lyase promotes the progression of nonalcoholic fatty liver disease

3.6.3 Mechanisms linking gut dysbiosis to PSCI 3.6.3.1 Neuroinflammation Gut dysbiosis and increased intestinal permeability following ischemic stroke (IS) have been linked to systemic endotoxemia and altered microbial metabolite signaling, potentially exacerbating neuroinflammation and injury (Zhang W