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The discrepancies between both studies could be due, at least in part, to the different anatomic injection site employed, since, as indicated above, thigh injections have been rated more painful than injections in the abdomen [25, 26]

However, a 2017 expert review and best-practice statement produced by the American Gastrointestinal Association (6) concluded that Long-term PPI users should not routinely raise their intake of vitamin B-12 beyond the Recommended Dietary Allowance (RDA) and that Long-term PPI users should not routinely screen or monitor vitamin B-12. Moreover, a 2014 commentary concluded that there is no evidence that pathological levels of the biochemical markers of B12 are more common in metformin-treated compared with nonmetformin-treated patients, despite lowering B12 in serum or plasma (7)

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All dosing described here documents a research protocol, not a prescription or personal recommendation