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Endo H, Niioka M, Kobayashi N, Tanaka M, Watanabe T (2013) Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis

Think of these proteins as the "cushioning" and "spring" in your skin's mattress

10.1038/nri2454 Nat Rev Immunol

Injectable dynamic hydrogel with responsive mechanical reinforcing ability reverses intervertebral disc degeneration by suppressing ferroptosis and restoring matrix homeostasis

Then, the core clock gene BMAL1 has been shown to act as a negative regulator of the target of rapamycin complex 1 (mTORC1), which acts as a master switch between cell anabolic and catabolic programs, thereby suppressing anabolism 82