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it is a severe exacerbation of systemic symptoms following even minor physical, cognitive, or emotional exertion

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In the presence of high PIP 3 concentration both AKT and PDK1 are recruited to the plasma membrane, through their pleckstrin homology (PH1) domains, where AKT undergoes a structural shift following association with PIP 3 increasing catalytic activity of PDK1 towards T308 AKT (Currie et al., 1999)

SYNGAP1 controls the maturation of dendrites, synaptic function, and network activity in developing human neurons