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PA-treated cells exhibited an increased mitochondrial ROS production, which was abrogated by fer-1, validating the important role of mitochondrial ROS in PA-induced ferroptosis only for SUM-159 cells (Figs

The final step of the oxPPP pathway, which produces the second molecule of NADPH, is catalysed by 6-phosphogluconate dehydrogenase (6PGD)

Acknowledgements We are grateful to Tibor Pli and Andrs Dr from the Institute of Biophysics, HUN-REN Biological Research Centre for providing access to the spectrofluorometer Fluorolog 3 (Horiba Jobin Yvon) and to the Malvern Zetasizer Nano ZS device (Malvern Instruments)