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Synaptic Vesicle Docking and Exocytosis Machinery Beyond SNARE proteins, the efficient docking and exocytosis of synaptic vesicles involve a highly orchestrated network of presynaptic proteins, including Munc13, Munc18, complexin, and synaptotagmin, many of which are tightly regulated by calcium dynamics [104]

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The one-to-three-hour dihexa half life remains constant throughout multi-day or multi-week protocols, which is why daily dosing maintains consistent peak plasma concentrations without dose escalation