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But it removes one biochemical stressor that can make existing vulnerabilities worse

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Geriatric Use ( 65 Years of Age) Because ketorolac tromethamine may be cleared more slowly by the elderly (see CLINICAL PHARMACOLOGY) who are also more sensitive to the dose-related adverse effects of NSAIDs (see WARNINGS - Gastrointestinal Effects - Risk of Ulceration, Bleeding, and Perforation), extreme caution and reduced dosages (see DOSAGE AND ADMINISTRATION) and careful clinical monitoring must be used when treating the elderly with ketorolac tromethamine

(2013) Cell , 155(7): 16241638 Landmark study demonstrating that declining NAD+ with age disrupts nuclear-mitochondrial communication, creating a pseudohypoxic state in ageing muscle

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