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The alleviation of hypoxic environment surrounding tumor sensitizing tumor cells to radiation therapy and photothermal therapy ( In addition to directly enhance the efficacy of antitumor treatment such as chemotherapy, phototherapy and radiotherapy, increasing O 2 level in vivo can change the expression of genes linked with tumor metabolism, proliferation and metastasis via regulating hypoxia-inducible factor 1 (HIF-1) pathway

Improvements were noted in pain intensity, pain frequency, and urinary symptoms

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Intermittent fasting (IF), another promising metabolic intervention, has demonstrated improvements in lipid profiles, oxidative stress, and insulin sensitivity in obesity-related disorders 14

Metabolites carrying Auger electrons selectively and locally irradiate the cell membrane and DNA, inducing cell death [7]