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According to multicenter retrospective analysis published in NIH databases, all three IL-5 inhibitors for asthma mepolizumab and benralizumabplus the IL-4/IL-13 inhibitor dupilumab show comparable effectiveness, but distinct mechanisms make each ideal for different patient profiles. Research from comparative effectiveness trials demonstrates that mepolizumab effectiveness specifically shines in patients with baseline eosinophils 300 cells/L, where exacerbation reductions reach 60-70%

Patients who should NOT use it include those with uncontrolled diabetes, active malignancy or personal history of hormone-sensitive cancer, or pituitary disease